Holders Barcelona will face Spanish counterparts, Atletico Madrid. The Catalans have won just one of their last 6 Champions League games against Spanish teams (D3 L2).
FC Bayern Munich who will play in the quarterfinals for a record 15th time will meet Benfica.
Real Madrid will battle VFL Wolfsburg, while Paris Saint Germain, who recently wrapped up the French Ligue 1 title will slug it out with Manchester City for a place in the Semi-finals.
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The quarter-finals will take place on 5-6 April and 12-13 April.
Full draw:
Wolfsburg v Real Madrid
Bayern Munich v Benfica
Barcelona v Atletico Madrid
Paris St-Germain v Manchester City
In the Europa League, Liverpool will face Borussia Dortmund, as Manger Jurgen Klopp handed a return to former side.
The 48-year old manager, left the German club in the summer of 2015, after two Bundesliga titles.
Holders, Sevilla who have won the trophy two-times in a row were drawn against Athletic Bilbao in an all-Spanish tie, while La-Liga counterpart, Villarreal will meet Sparta Prague.
Portuguese Side, Braga face a tough task against Shakhtar Donetsk of Ukraine.
The quarter-finals will be played on 7 and 14 April.
Full Draw:
Braga v Shakhtar Donetsk
Villarreal v Sparta Prague
Athletic Bilbao v Sevilla
Borussia Dortmund v Liverpool